Posted on June 29, 2016
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A population pharmacokinetic analysis was performed with data from 77 pediatric subjects (6 months to 12 years of age) with allergic rhinitis and 136adult subjects. The individual apparent oral clearance estimates of fexofenadine were on average 44% and 36% lower in pediatric subjects 6 to 12 years(n=14) and 2 to 5 years of age (n=21), respectively, compared to adult subjects..
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If your child is old enough, your doctor may also prescribe a steroid nasal spray such as Flonase, Nasonex or Rhinocort Aqua.. Allegra pediatrico 30mg 5ml senza ricetta.
The recommended dose of ALLEGRA oral suspension is 30 mg twice daily. Adose of 30 mg (5 mL) once daily is recommended as the starting dose in pediatric .
The recommended dose of Allegra tablets is 60 mg twice daily or 180 mg once daily with water. A dose of 60 mg once daily is recommended as thestarting dose in patients with decreased renal function [see Clinical Pharmacology (12.3)]..
Pediatrics: Table 2 lists adverse reactions in subjects aged 6 years to 11 years of age which were reported by greater than 2% of subjects treatedwith fexofenadine hydrochloride tablets at a dose of 30 mg twice daily in placebo-controlled seasonal allergic rhinitis studies in the United Statesand Canada.. Allegra pediatrico 30mg 5ml.
Table 3 lists adverse reactions in subjects 6 months to 5 years of age which were reported by greater than 2% of subjects treated with fexofenadinehydrochloride in 3 open single- and multiple-dose pharmacokinetic studies and 3 placebo-controlled safety studies with fexofenadine hydrochloridecapsule content (484 subjects) and suspension (50 subjects) at doses of 15 mg (108 subjects) and 30 mg (426 subjects) given twice a day..
Allegra pediatrico 30mg 5ml The carcinogenic potential of fexofenadine was assessed using terfenadine studies with adequate fexofenadine exposure (based on plasmaarea-under-the-concentration vs. time [AUC] values).. allegra d pediatrico para que sirve.
The recommended dose of Allegra oral suspension is 30 mg twice daily. A dose of 30 mg (5 mL) once daily is recommended as the starting dose inpediatric patients with decreased renal function [see Clinical Pharmacology (12.3)]..
Do not take other medications that contain erythromycin, ketoconazole or magnesium, or drink certain fruit juices, while taking Allegra. Doing so canincrease the risk of Allegra's side effects..allegra pediatrico 30mg 5ml.
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The safety data described below reflect exposure to fexofenadine hydrochloride in 5083 patients in trials for allergic rhinitis and chronic idiopathicurticaria. In these trials, 3010 patients 12 years of age and older with seasonal allergic rhinitis were exposed to fexofenadine hydrochloride atdoses of 20 to 240 mg twice daily or 120 to 180 mg once daily. A total of 646 patients 6 to 11 years of age with seasonal allergic rhinitis wereexposed to fexofenadine hydrochloride at doses of 15 to 60 mg twice daily. The duration of treatment in these trials was 2 weeks. A total of 534patients 6 months to 5 years of age with allergic rhinitis were exposed to fexofenadine hydrochloride at doses of 15 to 30 mg twice daily. Theduration of treatment in these trials ranged from 1 day to 2 weeks. There were 893 patients 12 years of age and older with chronic idiopathicurticaria exposed to fexofenadine hydrochloride at doses of 20 to 240 mg twice daily or 180 mg once daily. The duration of treatment in these trialswas 4 weeks.. Allegra pediatrico 30mg 5ml.
The pharmacokinetics of fexofenadine hydrochloride in subjects with seasonal allergic rhinitis and subjects with chronic urticaria were similar tothose in healthy subjects..
Allegra pediatrico 30mg 5ml Wheal and Flare. Human histamine skin wheal and flare studies in adults following single and twice daily doses of 20 and 40 mg fexofenadinehydrochloride demonstrated that the drug exhibits an antihistamine effect by 1 hour, achieves maximum effect at 2 to 3 hours, and an effect is stillseen at 12 hours. There was no evidence of tolerance to these effects after 28 days of dosing. The clinical significance of these observations isunknown.. allegra dosis pediatrico.
allegra pediatrico 30mg 5ml.Dizziness, drowsiness, and dry mouth have been reported with fexofenadine hydrochloride overdose. Single doses of fexofenadine hydrochloride up to 800mg (6 healthy subjects at this dose level), and doses up to 690 mg twice daily for 1 month (3 healthy subjects at this dose level) or 240 mg oncedaily for 1 year (234 healthy subjects at this dose level) were administered without the development of clinically significant adverse events ascompared to placebo..
Allegra ODT contains phenylalanine, a component of aspartame. Each 30 mg Allegra ODT contains 5.3 mg phenylalanine. Allegra products other thanAllegra ODT do not contain phenylalanine..
Provide the following information to patients and parents/caregivers of pediatric patients taking Allegra tablets, Allegra ODT or Allegra oralsuspension:.. Allegra pediatrico 30mg 5ml.
Nonteratogenic Effects: Dose-related decreases in pup weight gain and survival were observed in rats exposed to an oral dose of 150 mg/kg ofterfenadine (which led to fexofenadine exposures that were approximately 3 times the exposure at the maximum recommended human daily oral dose of 180mg of fexofenadine hydrochloride based on comparison of AUCs).. allegra pediatrico 30mg 5ml senza ricetta
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In one 4-week, multicenter, randomized, double-blind, placebo-controlled clinical trial in subjects 12 years of age and older with chronic idiopathicurticaria (n=259), fexofenadine hydrochloride 180 mg once daily significantly reduced the mean number of wheals (MNW), the mean pruritus score (MPS),and the mean total symptom score (MTSS, the sum of the MPS and MNW scores)..
allegra bula pediatrico Advise patients and parents/caregivers of pediatric patients to store the medication in a tightly closed container in a cool, dry place, away fromsmall children.. allegra pediatrico 30mg 5ml senza ricetta.
Clinical studies of Allegra tablets and capsules did not include sufficient numbers of subjects aged 65 years and over to determine whether thispopulation responds differently from younger subjects. Other reported clinical experience has not identified differences in responses between thegeriatric and younger subjects. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may begreater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken indose selection, and it may be useful to monitor renal function [see Clinical Pharmacology (12.3)]..
In placebo-controlled chronic idiopathic urticaria clinical trials, 726 subjects 12 years of age and older received fexofenadine hydrochloride tabletsat doses of 20 to 240 mg twice daily. Table 4 lists adverse reactions in subjects aged 12 years and older which were reported by greater than 2% ofsubjects treated with fexofenadine hydrochloride 60 mg tablets twice daily in controlled clinical studies in the United States and Canada.. allegra pediatrico 30mg 5ml senza ricetta.
Store away from heat, moisture, and light. Store in original packaging until justbefore use. Keep Allegra out of the reach of children and away from pets..
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