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Use only as additional therapy in patients with asthma currently receiving long-term asthma controller therapy (e.g., inhaled corticosteroids) butwhose disease is inadequately controlled with such therapy.188 221 248 257.. Advair ed.

Salmeterol is not a substitute for corticosteroids; corticosteroid therapy should not be stopped or reduced in dosage when salmeterol is initiated.1188 226 (See Concomitant Anti-inflammatory Therapy under Cautions.)..

 
 

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Particular care is needed during and after transfer of patients from systemic to inhaled corticosteroid therapy since death resulting from adrenalinsufficiency has occurred during and after such transfer.221 257 Do not use salmeterol in fixed combination with fluticasone inhalation aerosol totransfer patients from systemic corticosteroid therapy.257 Transfer of patients from systemic to inhaled corticosteroid therapy may unmask conditionspreviously suppressed by systemic corticosteroid therapy (e.g., rhinitis, conjunctivitis, eczema, arthritis, eosinophilic conditions)..

Remove cap covering mouthpiece of the aerosol inhaler.258 Look for foreign objects inside inhaler prior to use and check to see that canister is fullyseated within actuator.258.. Advair ed acquistare on-line .

Advair (Fluticasone Propionate, Salmeterol Xinafoate) side effects. Read about common and serious side.

Safety and efficacy of salmeterol oral inhalation powder in adolescents ≥12 years of age established based on trials conducted in adults andadolescents.188 (See Bronchospasm in Asthma under Uses.) However, data suggest that long-acting β2-adrenergic agonists may increase the risk ofasthma-related death and hospitalization in children and adolescents.188 221 257 (See Boxed Warning and also Asthma-related Death and Life-threateningEvents under Cautions.)..

Use of salmeterol in fixed combination with fluticasone inhalation powder in children 4–11 years of age with asthma is supported by data fromone clinical trial and from extrapolation of efficacy data from older patients.221 243 Safety and efficacy of such a combination in children.. Advair ed.

Shake the oral aerosol inhaler well for 5 seconds before each inhalation.257 258 Test spray inhaler 4 times into the air (away from face) beforeinitial use, and shake well for 5 seconds before each spray.257 258 If inhaler not used for >4 weeks or if inhaler was dropped, test spray inhalertwice into the air (away from face) and shake well for 5 seconds before each spray.257 258..

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Using Symbicort and Advair may cause drowsiness so patients should take care when driving or operating heavy machinery..

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Increased peak concentrations and AUC of salmeterol; possible increased risk of adverse cardiovascular effects 188 221 257.. Advair ed.

Kelly HW. Issues and advances in the pharmacotherapy of asthma. J Clin Pharm Ther. 1992; 17:271-81..

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advair ed.Advair Diskus should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma or COPD. AdvairDiskus has not been studied in patients with acutely deteriorating asthma or COPD..

Importance of adherence to dosing schedules, including not altering the dose or frequency of use unless otherwise instructed by a clinician.1 156 188221 253 257..

Food and Drug Administration. FDA drug safety communication: New safety requirements for long-acting inhaled asthma medications calledlong-acting beta-agonists (LABAs).. Advair ed.

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Ahlquist RP. Pharmacology of pressor agents on the systemic circulation. Seminars Drug Treat. 1973; 3:231-6..

Large safety study (Salmeterol Multicenter Asthma Research Trial [SMART]) showed an increase in asthma-related deaths in patients receivingsalmeterol.1 188 221 226 227 Because of similar mechanisms of action among long-acting β2-adrenergic agonists, these study findings areconsidered a class effect of these drugs.188 221 246 257 Data inadequate to determine whether concurrent use of inhaled corticosteroids or otherlong-term asthma controller therapy mitigates the risk of asthma-related death.188 221 257.. advair ed acquistare on-line .

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Distributed into milk in rats;38 188 not known whether distributed into human milk.253 Discontinue nursing or the drug.188.. advair ed acquistare on-line .

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Date July 6, 2014Author By Eric ChristiansonCategory Osteoporosis, Respiratory.. , , .