Posted on June 18, 2016
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Zovirax is used for treating chickenpox (varicella) or shingles (herpes zoster) and treating or suppressing genital herpes infections. Zovirax is anantiviral. It works by stopping viral replication. However, Zovirax does not eliminate the virus, is not a cure, and does not prevent transmission toothers.. Acyclovir dosis pediatrica.
After oral administration of ZOVIRAX, acyclovir concentrations have been documented in breast milk in 2 women and ranged from 0.6 to4.1 times the corresponding plasma levels. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to0.3 mg/kg/day. Nursing mothers who have active herpetic lesions near or on the breast should avoid nursing..
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Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2(HSV-2), and varicella-zoster virus (VZV)..
The quantitative relationship between the in vitro susceptibility of herpes viruses to antivirals and the clinical response to therapy has not beenestablished in humans, and virus sensitivity testing has not been standardized. Sensitivity testing results, expressed as the concentration of drugrequired to inhibit by 50% the growth of virus in cell culture (IC50), vary greatly depending upon a number of factors. Using plaque-reduction assays,the IC50 against herpes simplex virus isolates ranges from 0.02 to 13.5 mcg/mL for HSV-1 and from 0.01 to 9.9 mcg/mL for HSV-2.. Acyclovir dosis pediatrica user .
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Clinical experience has identified no interactions resulting from topical or systemic administration of other drugs concomitantly withZOVIRAX Cream..
Resistance of HSV and VZV to acyclovir can result from qualitative and quantitative changes in the viral TK and/or DNA polymerase. Clinical isolatesof HSV and VZV with reduced susceptibility to acyclovir have been recovered from immunocompromised patients, especially with advanced HIV infection.While most of the acyclovir-resistant mutants isolated thus far from immunocompromised patients have been found to be TK-deficient mutants, othermutants involving the viral TK gene (TK partial and TK altered) and DNA polymerase have been isolated. TK-negative mutants may cause severe disease ininfants and immunocompromised adults. The possibility of viral resistance to acyclovir should be considered in patients who show poor clinicalresponse during therapy.. Acyclovir dosis pediatrica.
Store away from heat, moisture, and light. Do not store in thebathroom. Keep Zovirax out of the reach of children and away from pets..
Acyclovir dosis pediatrica The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, cracked lips, burning skin,pruritus, flakiness of skin, and stinging on skin; each event occurred in less than 1% of patients receiving ZOVIRAX Cream and vehicle. Three patientson ZOVIRAX Cream and 1 patient on placebo discontinued treatment due to an adverse event.. acyclovir 800 mg compresse.
ZOVIRAX Cream was evaluated in 2 double-blind, randomized, placebo (vehicle)-controlled trials for the treatment of recurrent herpes labialis.The average patient had 5 episodes of herpes labialis in the previous 12 months. In the first study, median age was 37 years (range 18to 81 years), 74% were female, and 94% were Caucasian. In the second study, median age was 38 years (range 18 to 87 years), 73% werefemale, and 94% were Caucasian. Subjects were instructed to initiate treatment within 1 hour of noticing signs or symptoms and continue treatmentfor 4 days, with application of study medication 5 times per day. In both studies, the mean duration of the recurrent herpes labialisepisode was approximately one-half day shorter in the subjects treated with ZOVIRAX Cream (n = 682) compared with subjects treated withplacebo (n = 703) (approximately 4.5 days versus 5 days, respectively)..
Do not use ZOVIRAX Cream if you are allergic to ZOVIRAX (also known as acyclovir), VALTREX® (also known as valacyclovir), or any of theingredients of ZOVIRAX Cream. Ask your doctor or pharmacist about the inactive ingredients..
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The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viralenzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellularguanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. Thisis accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNAchain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared with VZV is due to its moreefficient phosphorylation by the viral TK.. Acyclovir dosis pediatrica.
In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of acyclovir cream.Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These events have been chosen forinclusion due to a combination of their seriousness, frequency of reporting, or potential causal connection to acyclovir cream..
Acyclovir dosis pediatrica Safety and effectiveness in pediatric patients less than 12 years of age have not been established.. acyclovir 200 mg compresse.
Before you start using ZOVIRAX Cream, tell your doctor if you are pregnant, planning to become pregnant, or are breast feeding..
Read this information before you start using ZOVIRAX (acyclovir) Cream and each time you refill your prescription. There may be new information. Thissummary is not meant to take the place of your doctor's advice. ..
Aciclovir is indicated for the treatment of HSV and VZV infections, including:.. Acyclovir dosis pediatrica.
ZOVIRAX is the brand name for acyclovir, a synthetic nucleoside analogue active against herpesviruses. ZOVIRAX Cream 5% is a formulation for topicaladministration. Each gram of ZOVIRAX Cream 5% contains 50 mg of acyclovir and the following inactive ingredients: cetostearyl alcohol,mineral oil, poloxamer 407, propylene glycol, sodium lauryl sulfate, water, and white petrolatum.. acyclovir dosis pediatrica user
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Zovirax is used for treating chickenpox (varicella) or shingles (herpes zoster) and treating or suppressing genital herpes infections..
acyclovir 800 effetti indesiderati Ask your health care provider any questions you may have about how to use Zovirax.. acyclovir dosis pediatrica user .
ZOVIRAX Cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation..
It is not known whether topically applied acyclovir is excreted in breast milk. Systemic exposure following topical administration is minimal.. acyclovir dosis pediatrica user .
Pregnancy Category B. Acyclovir was not teratogenic in the mouse, rabbit, or rat at exposures greatly in excess of human exposure. There are noadequate and well-controlled studies of systemic acyclovir in pregnant women. A prospective epidemiologic registry of acyclovir use during pregnancywas established in 1984 and completed in April 1999..
acyclovir 800 posologia Store Zovirax at room temperature, between 68 and 77 degrees F (20 and 25 degrees C).. acyclovir 800 mg dosaggio, acyclovir 800 mg prezzo, acyclovir 800 mg compresse prezzo.