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Pregnancy Category B. Acyclovir administered during organogenesis was not teratogenic in the mouse (450 mg/kg/day, p.o.), rabbit(50 mg/kg/day, s.c. and IV), or rat (50 mg/kg/day, s.c.).. Acyclovir 200 mg compresse.

Testicular atrophy and aspermatogenesis were observed in rats and dogs athigher dose levels..



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How Taken Treatment with Acyclovir topical should be started as soon as possible after the first appearance of symptoms (e.g. tingling, burning,blisters)..

Store away from heat, moisture, and light. Do not store in thebathroom. Keep Zovirax out of the reach of children and away from pets.. Acyclovir 200 mg compresse user .

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In a similar double-blind, placebo-controlled study, acyclovir (800 mg 5 times daily for 7 days) shortened the times to complete lesionscabbing, healing, and cessation of pain; reduced the duration of new lesion formation; and reduced the prevalence of localized zoster-associatedneurologic symptoms (paresthesia, dysesthesia, or hyperesthesia)..

Three randomized, double-blind, placebo-controlled trials were conducted in 993 pediatric patients aged 2 to 18 years with chickenpox. Allpatients were treated within 24 hours after the onset of rash. In 2 trials, acyclovir was administered at 20 mg/kg 4 times daily(up to 3,200 mg per day) for 5 days. In the third trial, doses of 10, 15, or 20 mg/kg were administered 4 times daily for 5 to7 days. Treatment with acyclovir shortened the time to 50% healing; reduced the maximum number of lesions; reduced the median number of vesicles;decreased the median number of residual lesions on day 28; and decreased the proportion of patients with fever, anorexia, and lethargy byday 2.. Acyclovir 200 mg compresse.

Caution should alsobe exercised when administering acyclovir to patients receiving potentially nephrotoxic agents since this may increase the risk of renal dysfunctionand/or the risk of reversible central nervous system symptoms such as those that have been reported in patients treated with intravenous acyclovir.Adequate hydration should be maintained..

Acyclovir 200 mg compresse Elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice.. .

The 323 placebo recipients reported malaise (11.1%)..

Acyclovir Peak and Trough Concentrations at Steady State..acyclovir 200 mg compresse.

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Acyclovir capsules are intended for oral ingestion only. Renal failure, in some cases resulting in death, has been observed with acyclovir therapy(see ADVERSE REACTIONS: Observed During Clinical Practice and OVERDOSAGE).. Acyclovir 200 mg compresse.

Elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice..

Acyclovir 200 mg compresse For patients who require hemodialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. This results in a 60%decrease in plasma concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule should be adjusted so that anadditional dose is administered after each dialysis.. .

acyclovir 200 mg compresse.The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viralenzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellularguanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA. Thisis accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNAchain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its moreefficient phosphorylation by the viral TK..

The 589control patients receiving intermittent treatment of recurrences with acyclovir for 1 year reported diarrhea (2.7%), nausea (2.4%), and headache(2.2%)..

The pharmacokinetics of acyclovir after oral administration have been evaluated in healthy volunteers and in immunocompromised patients with herpessimplex or varicella-zoster virus infection. Acyclovir pharmacokinetic parameters are summarized in Table 1.. Acyclovir 200 mg compresse.

The 589control patients receiving intermittent treatment of recurrences with acyclovir for 1 year reported diarrhea (2.7%), nausea (2.4%), and headache(2.2%).. acyclovir 200 mg compresse user

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Renal failure, elevated blood urea nitrogen, elevated creatinine, hematuria (see WARNINGS)..

Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS),which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy.. acyclovir 200 mg compresse user .

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The pharmacokinetics of acyclovir after oral administration have been evaluated in healthy volunteers and in immunocompromised patients with herpessimplex or varicella-zoster virus infection. Acyclovir pharmacokinetic parameters are summarized in Table 1.. acyclovir 200 mg compresse user .

In a similar double-blind, placebo-controlled study, acyclovir (800 mg 5 times daily for 7 days) shortened the times to complete lesionscabbing, healing, and cessation of pain; reduced the duration of new lesion formation; and reduced the prevalence of localized zoster-associatedneurologic symptoms (paresthesia, dysesthesia, or hyperesthesia)..

Acyclovir capsules are indicated for the treatment of chickenpox (varicella).. , , .