Posted on May 22, 2016
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The U.S. Food and Drug Administration (FDA) is warning that compulsive or uncontrollable urges to gamble, binge eat, shop, and have sex have beenreported with the use of the antipsychotic drug aripiprazole (Abilify, Abilify Maintena, Aristada, and generics). These uncontrollable urges werereported to have stopped when the medicine was discontinued or the dose was reduced. These impulse-control problems are rare, but they may result inharm to the patient and others if not recognized. Abilify effetti indesiderati.
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Aripiprazole is available under the brand names Abilify, Abilify Maintena, Aristada, and also as generics. Abilify effetti indesiderati acquistare on-line .
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We strongly advise health care professionals, patients, and caregivers to report side effects involving aripiprazole (Abilify, Abilify Maintena,Aristada) and other drugs to the FDA MedWatch program, using the information in the “Contact FDA” box at the bottom of the page. Abilify effetti indesiderati.
Abilify effetti indesiderati Although pathological gambling is listed as a reported side effect in the current aripiprazole drug labels, this description does not entirely reflectthe nature of the impulse-control risk that we identified. In addition, we have become aware of other compulsive behaviors associated witharipiprazole, such as compulsive eating, shopping, and sexual actions. These compulsive behaviors can affect anyone who is taking the medicine. As aresult, we are adding new warnings about all of these compulsive behaviors to the drug labels and the patient Medication Guides for all aripiprazoleproducts. abilify 10 mg compresse.
Patients and caregivers should be alert for uncontrollable and excessive urges and behaviors while taking aripiprazole. It is important to talk with ahealth care professional as soon as possible if you or a family member experiences any of these uncontrollable urges, in order to prevent or limitpossible harm. Patients should not suddenly stop taking their aripiprazole medicine without first talking to their health care professional.abilify effetti indesiderati.
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Health care professionals should make patients and caregivers aware of the risk of these uncontrollable urges when prescribing aripiprazole, andspecifically ask patients about any new or increasing urges while they are being treated with aripiprazole. Closely monitor for new or worseninguncontrollable urges in patients at higher risk for impulse-control problems. These include those with a personal or family history ofobsessive-compulsive disorder, impulse-control disorder, bipolar disorder, impulsive personality, alcoholism, drug abuse, or other addictivebehaviors. Consider reducing the dose or stopping the medicine if such urges develop. Abilify effetti indesiderati.
Abilify effetti indesiderati In the majority of cases, patients with no prior history of the compulsive behaviors experienced uncontrollable urges only after starting aripiprazoletreatment. Within days to weeks of reducing the dose or discontinuing aripiprazole, these uncontrollable urges stopped. abilify 5 mg e alcol.
abilify effetti indesiderati.All 167 FAERS cases reported that the patients experienced new urges leading to compulsive behavior only after starting aripiprazole treatment, andwithin days to weeks of reducing the dose or discontinuing aripiprazole treatment, all of these 167 patients reported that the intense urges resolved.None of the 167 patients had a history of pathological gambling, compulsive sexual behavior, binge eating, or compulsive shopping prior to startingaripiprazole treatment. Additionally, none of the 167 patients had concurrent substance abuse disorder (including alcohol use disorder) or symptoms ofmania (such as rapid speech, feelings of grandiosity, or reduced need for sleep) at the time they developed impulse-control problems. Reasons foraripiprazole treatment reported in the cases included, but were not limited to, schizophrenia, schizoaffective disorder, bipolar mood disorder, majordepressive disorder, and anxiety disorders.
A search of the FDA Adverse Event Reporting System (FAERS) database and the medical literature in the 13 years since the approval of the firstaripiprazole product (Abilify) in November 2002 identified a total of 184 case reports in which there was an association between aripiprazole use andimpulse-control problems. There were 167 U.S. cases, which included adults and children. Pathological gambling was the most common (164 cases), butother compulsive behaviors including compulsive eating, spending or shopping, and sexual behaviors were also reported (see Data Summary). FAERSincludes only reports submitted to FDA, so there may be additional cases about which we are unaware. In order to provide context for thesedrug-associated events, approximately 1.6 million patients received an aripiprazole prescription from U.S. outpatient retail pharmacies during 2015.1 Abilify effetti indesiderati.
A search of the FDA Adverse Event Reporting System (FAERS) database and the medical literature since the approval of the first aripiprazole product(Abilify) in November 2002 through mid-January 2016 identified 184 case reports (167 FAERS cases and 17 medical literature cases) indicating anassociation between aripiprazole and impulse-control problems. The specific impulse-control problems reported include: pathological gambling (n=164);compulsive sexual behavior (n=9); compulsive buying (n=4); compulsive eating (n=3); and multiple impulse-control problems (n=4). abilify effetti indesiderati acquistare on-line
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a cosa serve il farmaco abilify Of the 17 cases published in the medical literature, all cases contained information that the compulsive behavior resolved completely whenaripiprazole was discontinued, and four cases reported the return of compulsive behaviors when aripiprazole was restarted. These four cases describeda close temporal relationship, within days to weeks, of initiating aripiprazole and the onset of hypersexual behavior (n=3) or pathological gambling(n=1). The patients who experienced hypersexual behavior noticed the behavior when they first started aripiprazole, hypersexuality resolved afterdiscontinuing the drug, and then reappeared after restarting it. In the case describing pathological gambling, the patient experienced an escalationin gambling after starting aripiprazole. The patient was able to significantly reduce his gambling after discontinuing the drug, but uncontrollableurges to gamble returned after he was restarted on aripiprazole. abilify effetti indesiderati acquistare on-line .
Aripiprazole is used to treat certain mental disorders, including schizophrenia, bipolar disorder, Tourette’s disorder, and irritabilityassociated with autistic disorder. It may also be used in combination with antidepressants to treat depression. Aripiprazole can decreasehallucinations and other psychotic symptoms such as disorganized thinking. It can stabilize mood, improve depression, and decrease the tics ofTourette’s disorder. abilify effetti indesiderati acquistare on-line .
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