Posted on May 19, 2016
abilify e schizofrenia
Schizophrenia is a chronic disorder characterized by frequent relapses that have severe consequences for patients' quality of life, includingoccupational and psychosocial function, as well as economic burden for the patients and their families. Since patients may not return to previouslevels of functioning following relapse (Emsley et al., 2013 and Lieberman et al., 2006), early treatment intervention is important and has thepotential to change the course of the illness (Stahl, 2014). Another prerequisite for successful treatment is patient adherence, which is often poorin schizophrenia (Perkins, 2002). Abilify e schizofrenia.
Abilify e schizofrenia - Lee mas
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The QUALIFY (QUAlity of LIfe with AbiliFY Maintena®) study is one of very few randomized studies that directly compare two atypical LAIs and is thefirst to compare two atypical LAIs with different mechanisms of action on health-related quality of life and functioning. Previous head-to-headstudies have compared effects of LAIs on classical measures of psychopathology and have consistently showed non-inferiority between different LAIs(Fleischhacker et al., 2012, Li et al., 2011 and Pandina et al., 2011). Superiority of one atypical LAI vs another has not been previouslydemonstrated. Abilify e schizofrenia senza ricetta.
Durante gli ultimi 10-15 anni la commercializzazione degli antipsicotici di seconda generazione, chiamati anche atipici, ha ampliato le possibilità di trattamento .
Posted in: Medical Condition News | Pharmaceutical News Abilify e schizofrenia.
Abilify e schizofrenia Long-acting injectable antipsychotics (LAIs) may increase long-term adherence to treatment and may reduce the risk of relapse and improve patientfunctioning (Kishimoto et al., 2013). Both aripiprazole once-monthly 400 mg (AOM 400) and paliperidone palmitate once-monthly (PP) are atypical LAIswith demonstrated efficacy in schizophrenia (Fleischhacker et al., 2014, Hough et al., 2010, Kane et al., 2012 and Nasrallah et al., 2010). However,they have different pharmacological mechanisms: aripiprazole is a partial agonist at dopamine D2 and serotonin 5-HT1A receptors and an antagonist at5HT2A receptors while paliperidone is an antagonist at D2 and 5HT2A receptors. In addition to efficacy, an acceptable tolerability profile isimportant for long-term treatment (Hasan et al., 2013), and studies of treatment effectiveness (comprising both efficacy and tolerability) on moreclinically relevant endpoints beyond traditional psychopathology are necessary to evaluate the effect of treatments on patient functioning and qualityof life, both of which are inversely predictive of relapse (Boyer et al., 2013). abilify 10 mg scheda tecnica.
The Heinrichs–Carpenter Quality-of-Life Scale (QLS) was selected as the primary endpoint reflecting a key long-term treatment goal for both clinicianand patient. It is a clinician-rated scale derived from a semi-structured patient interview that is widely used in psychopharmacological evaluation oftreatments for schizophrenia (Lewis et al., 2006). The QLS is a health-related quality-of-life scale focused on intrapsychic, social, and negativesymptoms and their consequences for functioning in schizophrenia (Heinrichs et al., 1984). The QLS total score measures effects beyond functioning inpatients with schizophrenia; it also assesses the richness of personal experience, the quality of interpersonal relations, and productivity inoccupational roles.
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The primary objective of this study was to compare the effectiveness of 28-week treatment with AOM 400 to PP in adult patients with schizophrenia onthe QLS using a non-inferiority hypothesis; if met, a pre-defined test of superiority would be conducted. Additional objectives were to compare safetyand tolerability of the treatments. Abilify e schizofrenia.
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