Posted on May 29, 2016






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The compressed tablets are extensively absorbed through the gastrointestinal tract with a bioavailability of 87%. The time to peak plasmaconcentration (Tmax) is 3–5 hours for aripiprazole; food intake does not significantly affect peak plasma concentration (Cmax) but may delayTmax.4 Aripiprazole exhibits linear pharmacokinetics between the dosing ranges of 5–30 mg/day. At equivalent doses (ie, 30 mg/day), the plasmaconcentration of aripiprazole oral solution was higher than that of the compressed tablet, ie, the solution-to-tablet ratio of geometric Cmax and areaunder concentration-time curve (AUC) values were 122% and 114%. Aripiprazole oral disintegrating tablets are bioequivalent to the compressed tablets.The time to peak plasma concentration with aripiprazole injection is 1–3 hours and has an absolute bioavailability of 100%. The geometric meanCmax achieved after an intramuscular (IM) dose was approximately 19% higher than the Cmax of the oral tablet; the aripiprazole AUC in the first 2hours after the initial IM injection is 90% greater than the AUC after a similar tablet dose. Over 24 hours of dosing, the systemic exposure issimilar between aripiprazole injection and oral tablet administration.3 Abilify pasticche.



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