Posted on June 2, 2016

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Collective data from 17 placebo-controlled clinical studies involving the use of atypical antipsychotic agents in the elderly patient with dementiashowed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration forthe trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure,sudden death) or infectious (e.g., pneumonia) in nature. Although aripiprazole was not included in these studies, the consistent findings across allthree relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents.Aripiprazole is not indicated for use in the treatment of behavioral disorders in elderly patients with dementia.[Ref]

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